UNF special seminar

False Discovery Rate Control Under Rounding of P-Values Dr Hien Nguyen Location : CRIUGM (http://www.criugm.qc.ca/en/contact.html), room M6804 Date: December 13th, 13h-14h The seminar will be presented in English Dr Hien Nguyen is going to give special seminar of Unité de Neuroimagerie Fonctionnelle (UNF) this coming Wednesday. Dr Nguyen is a Lecturer and Australia Research Council DECRA Research Fellow at La Trobe University in Melbourne Australia. His research currently focuses on the development of Big Data methodologies that are deployable on small-scale computing infrastructures, and deep learning and neural networks for applications in personalised medicine. Summary: The mitigation of false positives is an important issue when conducting multiple hypothesis testing. The most popular paradigm for false positives mitigation is via the control of the false discovery rate (FDR). We present a method for FDR control that is applicable in cases where only p-values are available, and when those p-values are potentially equal to zero or one. Our method is based on an empirical-based paradigm where the Probit transformation of the p-values (called the z-scores) are modeled as a two-component mixture of normal distributions. Due to the rounding of the p-values, the usual approach for fitting mixture models cannot be applied. We instead use a binned data technique, which can be proved to consistently estimate the z-score distribution, even when the data are correlated. A simulation study shows that our methodology is competitive with popular alternatives, especially when data are correlated. We demonstrate the applicability of our methodology in practice via a brain imaging study of...

UNF 10th Anniversary

It is with great pleasure that we invite you to celebrate the 10th anniversary of the Functional neuroimaging unit (UNF). For this occasion, three internationally renowned researchers will share the latest knowledge in their respective fields. We will welcome you on Monday, September 22nd, 2014 at 1:00 p.m.at the Amphitheatre National Bank, Hautes Études Commerciales (HEC), 3000 Chemin de la Côte-Sainte-Catherine. A detailed program will follow shortly.   Adrian Owen, Ph.D. Brain and Mind Institute Department of Psychology University of Western Ontario, London, Ontario, Canada http://www.owenlab.uwo.ca/   “The search for consciousness: what has neuroimaging told us?” Randy McIntosh, Ph.D. Director, Rotman Research Institute Vice President Research, Baycrest Centre, Toronto, Canada http://www.baycrest.org/research/rotman-research-institute/labs-and-programs/mcintosh-lab/   “Does building a virtual brain to understand human cognition makes sense?”   Denis Le Bihan, M.D., Ph.D. Director, NeuroSpin, France http://www.meteoreservice.com/dlb.htm   “ What water tells us about the brain: The magic of diffusion MRI”...

Welcome to the UNF

The UNF (Unité de Neuroimagerie Fonctionnelle) of the Centre de recherche de l’Institut universitaire de gériatrie de Montréal (CRIUGM) is solely dedicated to research in neuroimaging. Researchers from Université de Montréal and affiliates (research centers and faculty members) from Canada and around the globe can benefit from its state-of-the-art...